Occult Primary Head and Neck Squamous Cell Carcinoma

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Occult primary head and neck carcinoma.

Unknown primary carcinoma presenting as cervical lymph node metastasis accounts for approximately 5% of all head and neck malignancies. The typical presentation involves a middle-aged man with a painless neck mass that has been present for several months. Over 90% of these malignancies represent squamous cell carcinoma originating within Waldeyer's ring (lymphoid tissue of the nasopharynx, tons...

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Epithelial-Mesenchymal Transition and Inflammation in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

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Viable biobanking of primary head and neck squamous cell carcinoma.

OBJECTIVES/HYPOTHESIS To determine the feasibility of viable storage of head and neck squamous cell carcinoma (HNSCC) for regrowth of cells in culture. STUDY DESIGN Laboratory-based translational study. METHODS Methods for intermediate-term frozen storage of viable HNSCC were explored using small pieces of primary tumor and dissociated HNSCC cells after short-term culture. Viable cells afte...

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Density of mast-cells and Microvessels Density in head and neck cutaneous Squamous Cell Carcinoma

Background and Aim: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Mast cells may play a role in tumor progression and metastasis by increasing angiogenesis. The aim of this study was to investigate the role of mast cells by increasing angiogenesis in invasion of head and neck cutaneous squamous cell carcinoma. Materials and Methods: In this cross-sectional stud...

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Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: metastasis or second primary?

PURPOSE To distinguish a metastasis from a second primary tumor in patients with a history of head and neck squamous cell carcinoma and subsequent pulmonary squamous cell carcinoma. EXPERIMENTAL DESIGN For 44 patients with a primary squamous cell carcinoma of the head and neck followed by a squamous cell carcinoma of the lung, clinical data, histology, and analysis of loss of heterozygosity (...

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ژورنال

عنوان ژورنال: Otolaryngology–Head and Neck Surgery

سال: 2014

ISSN: 0194-5998,1097-6817

DOI: 10.1177/0194599814533494